| 1. |
Introduction |
| 1.1. |
Scope |
| 1.2. |
Terms of Reference |
| 1.3. |
Methodology |
| 1.4. |
Who is This Report For? |
| 2. |
Executive Summary |
| 2.1. |
Main Findings |
| 2.2. |
Main Conclusions |
| 2.3. |
Global Bio-Detection Market Forecast – 2010-2014 |
| 2.3.1. |
Global Systems, Service & Upgrade Markets – 2010-2014 |
| 2.3.2. |
Markets by Countries & Regions – 2010-2014 |
| 2.3.3. |
Markets by Outdoor, Indoor, Hand-Held and Mobile Lab – 2010-2014 |
| 2.3.4. |
Systems Market by Technology Generation – 2010-2014 |
| 2.3.5. |
Service & Upgrade Market by Generation – 2010-2014 |
| 2.4. |
Business Opportunities |
| 2.4.1. |
Bio-Surveillance, Detection & Bio-forensics Business Challenges – 2010-2014 |
| 2.5. |
Technology Outlook |
| 3. |
Bio-Terror |
| 4. |
Forty Countries: Bio-Security Status Review |
| 4.1. |
Background |
| 4.1.1. |
Forty Countries Bio-Technology & Bio-Defense Performance Score |
| 5. |
Market Drivers |
| 6. |
Market Inhibitors |
| 7. |
Bio-Detection Industry Competitive Analysis |
| 8. |
Industry SWOT Analysis |
| 8.1. |
Scope |
| 8.2. |
SWOT Analysis |
| 9. |
The Bio-Detection Process |
| 9.1. |
Sampling the Environment |
| 9.2. |
Bio-Detectors in a Multitude of Ambient Settings |
| 9.3. |
Bio-Detection Triggering |
| 9.4. |
Sample Collection |
| 9.5. |
Bio-Particle Detectors |
| 9.6. |
Bio-Agent Identification |
| 10. |
Bio-Detection Technological Challenges |
| 10.1. |
Challenge 1 – Detection of Small Particle Concentration |
| 10.2. |
Challenge 2 – Bio-Background Suppression |
| 10.3. |
Challenge 3 – Expensive Reagents |
| 10.4. |
Challenge 4 – Expensive Equipment Maintenance |
| 10.5. |
Challenge 5 – Adapting Equipment to Changing Environments |
| 10.6. |
Challenge 6 – Dealing With Emerging Threats |
| 11. |
Present and Pipeline Bio-Detection Technologies |
| 11.1. |
Bio-Detection – Core Technologies Comparison |
| 11.2. |
Collector/Concentrator Core Technologies |
| 11.3. |
Cyclone Collectors |
| 11.4. |
Variable Particle-Size Impactor |
| 11.5. |
Virtual Impactors |
| 11.6. |
Impingers |
| 11.7. |
Reagent-less Trigger Core Technologies |
| 11.7.1. |
Flow Cytometry |
| 11.7.2. |
Particle Sizing |
| 11.7.3. |
Gas Chromatography |
| 11.7.4. |
Trigger Technologies – Drivers |
| 11.7.5. |
Trigger Technologies – Inhibitors |
| 11.8. |
DNA Based Diagnostic Core Technologies |
| 11.8.1. |
Overview of DNA-Based Detection |
| 11.8.2. |
Polymerase Chain Reaction (PCR) |
| 11.8.3. |
DNA / RNA Microarrays |
| 11.8.4. |
DNA Technology Drivers |
| 11.8.5. |
DNA Technology Inhibitors |
| 11.9. |
Antibody-Antigen Diagnostic Core Technologies |
| 11.9.1. |
Overview of Antibody-Antigen Reaction |
| 11.9.2. |
Hand-Held Immuno-Chromatographic Assays (HHA) |
| 11.9.3. |
Magnetic Microbead-Base Assays |
| 11.9.4. |
Microfluidic Devices – “Lab on a Chip” |
| 11.9.5. |
Fluorescence Imaging |
| 11.9.6. |
Electrochemical-Luminescence (ECL) |
| 11.9.7. |
Antibody/Antigen Technology – Drivers |
| 11.9.8. |
Antibody/Antigen Technology – Inhibitors |
| 11.1. |
Signal Analysis Algorithms |
| 11.10.1. |
Clustering / Classifier Algorithms |
| 11.10.2. |
Image Analysis Algorithms |
| 11.10.3. |
Decision Algorithms |
| 11.10.4. |
Drivers |
| 11.10.5. |
Inhibitors |
| 11.11. |
Rapid Microbiological Technologies |
| 12. |
Bio- Detection – Analysis by Application |
| 12.1.1. |
Application 1 – Emergency Responder Hand-Held Detectors |
| 12.1.2. |
Application 2 – Emergency Responder Mobile Labs |
| 12.1.3. |
Application 3 – Indoor Standoff Detectors |
| 12.1.4. |
Application 4 – Outdoor Standoff Detectors |
| 13. |
Global Bio- Detection Market – 2010-2014 |
| 13.1. |
The Global Market Overview |
| 13.2. |
Markets by Systems, Upgrade and Service Segments – 2010-2014 |
| 13.3. |
Global Market by Countries & Regions – 2010-2014 |
| 13.4. |
Global Systems Market by Technological Generation – 2010-2014 |
| 13.5. |
Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments – 2010-2014 |
| 13.6. |
Global Service & Upgrade Market by Technological Generation – 2010-2014 |
| 13.6.1. |
Global Service and Upgrade Business by Technological Generation – 2010-2014 |
| 13.6.2. |
Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments – 2010-2014 |
| 14. |
US Bio-Detection Market – 2010-2014 |
| 14.1. |
Leading Bio-Security Projects |
| 14.1.1. |
Project BioWatch |
| 14.1.2. |
Project BioSense |
| 14.1.3. |
Project BioShield |
| 14.2. |
US Bio-Defense Background & Analysis |
| 14.3. |
US Bio-Defense Funding |
| 14.3.1. |
DHHS Bio-Defense Missions and Funding |
| 14.3.2. |
DHS Bio-Defense Missions and Funding |
| 14.3.3. |
DOD Bio-Defense Missions and Funding |
| 14.3.4. |
DOA Bio-Defense Missions and Funding |
| 14.3.5. |
EPA Bio-Defense Missions and Funding |
| 14.3.6. |
Other Bio-Defense Missions and Funding |
| 14.4. |
The Obama Administration Bio-Defense Strategy |
| 14.5. |
Market Drivers |
| 14.6. |
Market Inhibitors |
| 14.7. |
US Bio-Detection Systems Market – 2010-2014 |
| 14.7.1. |
Sales by Generation Forecast |
| 14.7.2. |
US Bio-Detection Systems Market by Modality Forecast |
| 14.8. |
US Outdoor Standoff Bio-Detection Systems Market – 2010-2014 |
| 14.8.1. |
Sales Outlook |
| 14.9. |
US Indoor Bio-Detection Systems Market – 2010-2014 |
| 14.9.1. |
Indoor Market Outlook |
| 14.1. |
US Hand-Held Detection Systems Market – 2010-2014 |
| 14.10.1. |
Hand-Held Detection Systems Market Outlook |
| 14.11. |
US Mobile Bio-Detection Labs Market – 2010-2014 |
| 14.11.1. |
Market Outlook |
| 14.12. |
US Service Business – 2010-2014 |
| 14.12.1. |
Service & Upgrade Business by Modality – 2010-2014 |
| 14.12.2. |
Service Business by Generation – 2010-2014 |
| 15. |
The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market |
| 15.1. |
The European Union |
| 15.1.1. |
The European Union Bio-Defense Background |
| 15.1.2. |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |
| 15.1.3. |
EU Bio-Defense Research Programs |
| 15.2. |
The UK |
| 15.2.1. |
Bio-Defense Strategy |
| 15.2.2. |
Main Bio-Defense Initiatives |
| 15.3. |
Germany |
| 15.3.1. |
Bio-Defense Strategy |
| 15.3.2. |
Main Bio-Defense Initiatives |
| 15.3.3. |
Bio- Detection R&D Projects |
| 15.4. |
France |
| 15.5. |
Italy |
| 15.6. |
Spain |
| 15.7. |
Market Drivers |
| 15.8. |
Market Inhibitors |
| 15.9. |
UK, Germany, France, Italy and Spain Bio-Detection Systems Market – 2010-2014 |
| 15.9.1. |
Sales by Technology Generations Forecast |
| 15.9.2. |
Sales by Modality Forecast |
| 15.1. |
UK, Germany, France, Italy and Spain Outdoor Standoff Bio-Detection Systems Market Forecast – 2010-2014 |
| 15.10.1. |
Systems Market Outlook |
| 15.11. |
UK, Germany, France, Italy and Spain Indoor Bio-Detection Systems Market – 2010-2014 |
| 15.11.1. |
Systems Market Outlook |
| 15.12. |
UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market – 2010-2014 |
| 15.12.1. |
Systems Market Outlook |
| 15.13. |
UK, Germany, France, Italy and Spain Mobile Bio-Detection Labs Market – 2010-2014 |
| 15.13.1. |
Market Outlook |
| 15.14. |
UK, Germany, France, Italy and Spain Service Business – 2010-2014 |
| 15.14.1. |
Service & Upgrade Business by Modality – 2010-2014 |
| 15.14.2. |
Service Business by Generation – 2010-2014 |
| 16. |
China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market |
| 16.1. |
Asian Countries Bio- Defense Background |
| 16.2. |
Japan |
| 16.3. |
China |
| 16.4. |
Taiwan |
| 16.5. |
India |
| 16.6. |
Singapore |
| 16.7. |
Middle East |
| 16.8. |
Market Drivers |
| 16.9. |
Market Inhibitors |
| 16.1. |
China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market – 2010-2014 |
| 16.10.1. |
Sales by Technology Generation – 2010-2014 |
| 16.10.2. |
Market by Modality – 2010-2014 |
| 16.11. |
China, Taiwan, Japan, India and Middle East Bio-Detection Outdoor Systems Market – 2010-2014 |
| 16.11.1. |
Sales Outlook |
| 16.12. |
China, Taiwan, Japan, India and Middle East Bio-Detection Indoor Systems Market – 2010-2014 |
| 16.12.1. |
Market Outlook |
| 16.13. |
China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market – 2010-2014 |
| 16.13.1. |
Market Outlook |
| 16.14. |
China, Taiwan, Japan, India and Middle East Bio-Detection Mobile Labs Market – 2010-2014 |
| 16.14.1. |
Market Outlook |
| 16.15. |
China, Taiwan, Japan, India and Middle East Service Business – 2010-2014 |
| 16.15.1. |
Service & Upgrade Business by Modality – 2010-2014 |
| 16.15.2. |
Service Business by Generation – 2008-2014 |
| 17. |
The Rest of the World HLS-HLD Bio-Detection Market |
| 17.1. |
ROW: Bio-Defense Background |
| 17.1.1. |
Russia and CIS |
| 17.1.2. |
Russian Government Bio-Security Initiatives |
| 17.1.3. |
International Science and Technology Center (ISTC) |
| 17.1.4. |
Canada |
| 17.1.5. |
Australia |
| 17.2. |
Market Drivers |
| 17.3. |
Market Inhibitors |
| 17.4. |
ROW Bio-Detection Systems Market – 2010-2014 |
| 17.4.1. |
Sales Forecast by Generation |
| 17.4.2. |
Market by Modality Forecast |
| 17.5. |
ROW Outdoor Bio-Detection Systems Market – 2010-2014 |
| 17.5.1. |
Sales Outlook |
| 17.6. |
ROW Indoor Bio-Detection Systems Market – 2010-2014 |
| 17.6.1. |
Market Outlook |
| 17.7. |
ROW Hand-Held Detection Systems Market – 2010-2014 |
| 17.7.1. |
ROW Market Outlook |
| 17.8. |
ROW Mobile Bio-Detection Labs Market – 2010-2014 |
| 17.8.1. |
Market Outlook |
| 17.9. |
ROW Service Business – 2010-2014 |
| 17.9.1. |
ROW Service & Upgrade Business by Modality |
| 17.9.2. |
Service Business by Generation – 2010-2014 |
| 18. |
Bio-Detection Business Opportunities – 2010-2014 |
| 18.1. |
Historical Perspective: A Market Waiting for Transition |
| 18.1.1. |
The Current and Future HLS Bio-Defense Strategy for Detection |
| 18.1.2. |
Factors Affecting Biological Detectors Deployment and Technologies – 2010-2014 |
| 18.1.3. |
Biological Detection Technology Timeline – 1992-2014 |
| 18.2. |
Business Opportunities for Next Generation HLS Bio-Detection Systems |
| 18.2.1. |
Business Opportunity 1 – Emerging Threats |
| 18.2.2. |
Business Opportunity 2 – Human Sentinel Surveillance System |
| 18.2.3. |
Business Opportunity 3 – Animal Sentinel Surveillance System |
| 18.2.4. |
Business Opportunity 4 – Biological IC3 – Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure |
| 18.2.5. |
Business Opportunity 5 – Reducing False Alarms – Less False Positives and False Negatives |
| 18.2.6. |
Business Opportunity 6 – Reducing Cost – Minimizing Use of Non-Reusable Reagents |
| 18.3. |
Outdoor Standoff Biological Detectors |
| 18.3.1. |
Business Opportunity 7 – Bio-agent Autonomous Networked Detectors (BAND) |
| 18.3.2. |
Business Opportunity 8 – Rapid Automated Biological Identification System (RABIS) |
| 18.3.3. |
Business Opportunity 9 – First Responder Portable Hand-Held Detector |
| 18.3.4. |
Business Opportunity 10 – First-Responder Mobile Biological Detection Station |
| 18.3.5. |
Business Opportunity 11 – Regional Automatic Detector – Outdoor Standoff Detectors |
| 18.3.6. |
Business Opportunity 12 – Networked Automatic Detector – Indoor Standoff Detectors |
| 18.3.7. |
Business Opportunity 13 – External Dissemination of Bio-Agent Detection |
| 18.3.8. |
Business Opportunity 14 – Internal Dissemination of Bio-Agent |
| 18.4. |
Other Bio-Detection Technologies – Business Opportunities |
| 18.4.1. |
Business Opportunity 15 – “Lab on a Chip” – Miniature Detection Devices |
| 18.4.2. |
Business Opportunity 16 – Reagent-less Specific Detection Assays |
| 18.4.3. |
Business Opportunity 17 – Laser-Induced Breakdown Spectroscopy (LIBS) |
| 18.4.4. |
Business Opportunity 18 – Raman Spectroscopy-based Reagent-less Detection |
| 18.5. |
Future Technologies and Systems |
| 19. |
Bio-Defense U.S. Federal R&D Funding – 2010-2014 |
| 19.1. |
Summary & Outlook |
| 19.2. |
Bio-Defense Federal R&D Funding Forecast – 2010-2014 |
| 19.2.1. |
Department of Homeland Security Bio-Security R&D |
| 19.2.2. |
Department of Defense Bio-Security R&D |
| 19.2.3. |
Department of Health and Human Services Bio-Security R&D |
| 19.2.4. |
Other Agencies Bio-Security R&D |
| 19.3. |
HLS-HLD Bio-Detection R&D Funding – Drivers |
| 19.4. |
HLS-HLD Bio-Detection R&D Funding – Inhibitors |
| 19.5. |
Department of Homeland Security – Biological Detection HLS Technologies R&D Programs |
| 19.5.1. |
Surveillance and Detection R&D |
| 19.5.2. |
Rapid Development for Sensors for Novel Threat Agents |
| 19.5.3. |
Cross Correlation of Environmental Biological Sensors and Human Illness |
| 19.5.4. |
Facility Airborne Biological Toxin Alarm System (FABTAS) |
| 19.5.5. |
Field-Deployable Detection Technology for the Identification of Biological Toxins |
| 19.5.6. |
Forensics |
| 19.6. |
Defense Advanced Research Project Agency (DARPA) – Biological Detection HLS Technologies R&D Programs |
| 19.6.1. |
Hand-held Isothermal Silver Standard Sensor (HISSS) |
| 19.6.2. |
Triangulation Identification for Genetic Evaluation of Biological Risk (TIGER) |
| 19.6.3. |
Spectral Sensing of Bio-Aerosols (SSBA) |
| 19.6.4. |
Threat Agent Cloud Tactical Intercept Countermeasure (TACTIC) |
| 19.6.5. |
Immune Buildings |
| 19.7. |
Chemical Biological Defense Program (CBDP) – Biological Detection HLS Technologies R&D Programs |
| 19.7.1. |
Project CB1 – Biological Defense (Basic Research) – Detection |
| 19.7.2. |
Project CB2 – Biological Defense (Applied Research) – Detection |
| 19.7.3. |
Project CB3 – Biological Defense (ATD) – Detection |
| 19.7.4. |
Project CA5 Contamination Avoidance (SDD) |
| 19.8. |
Technical Support Working Group (TSWG) – Biological Detection HLS Technologies R&D Programs |
| 19.8.1. |
Real-Time Biological Aerosol Detection |
| 20. |
Vendors |
| 20.1. |
20/20 GeneSystems Inc. |
| 20.2. |
Advnt Biotechnologies |
| 20.3. |
Agilent Technologies |
| 20.4. |
Alexeter Technologies |
| 20.5. |
ANP Technologies, Inc. |
| 20.6. |
BAS – Biological Alarm Systems Ltd. (Israel) |
| 20.7. |
BD Biosciences Immunocytometry Systems |
| 20.8. |
Bertin Technologies |
| 20.9. |
BioDefense Corporation |
| 20.1. |
BioDETECT AS |
| 20.11. |
BioSentinel Pharmaceuticals LLC |
| 20.12. |
3M Microbiology (Biotrace International, Ltd.) |
| 20.13. |
BioTraces, Inc. |
| 20.14. |
BioVeris Corporation |
| 20.15. |
Biral |
| 20.16. |
Cepheid |
| 20.17. |
Commonwealth Biotechnologies, Inc. |
| 20.18. |
Dycor Technologies Ltd. |
| 20.19. |
Environics Oy |
| 20.2. |
Evogen, Inc. |
| 20.21. |
General Dynamics Canada |
| 20.22. |
GenPrime, Inc. |
| 20.23. |
Groton Biosystems |
| 20.24. |
Haztech Systems, Inc. |
| 20.25. |
Idaho Technology, Inc. |
| 20.26. |
JMAR Technologies, Inc. |
| 20.27. |
New Horizons Diagnostics |
| 20.28. |
Proengin |
| 20.29. |
QTL Biodetection |
| 20.3. |
Research International |
| 20.31. |
Response Biomedical |
| 20.32. |
Roche Applied Science |
| 20.33. |
Smiths Detection |
| 20.34. |
Tetracore, Inc. |
| 21. |
Prices of Bio-Detection Equipment |
| 22. |
Pricing Outlook – 2010-2014 |
| 23. |
Bio-Detection – Economic Considerations |
| 24. |
Bio-Detection – Personnel Considerations |
| 25. |
Appendix A: The Threat of Bio-Terror |
| 25.1. |
Biological Terror |
| 25.2. |
Bio-Weapons – Historical Perspective |
| 25.3. |
Biological Terror – Bacterial Agents |
| 25.3.1. |
Anthrax |
| 25.3.2. |
Cholera |
| 25.3.3. |
Plague |
| 25.3.4. |
Tularemia |
| 25.4. |
Biological Terror – Viral Agents |
| 25.4.1. |
Smallpox |
| 25.4.2. |
Hemorrhagic Fever Viruses |
| 25.4.3. |
Venezuelan Equine Encephalitis |
| 25.5. |
Biological Terror – Rickettsiae Agents |
| 25.5.1. |
Q Fever |
| 25.5.2. |
Typhus |
| 25.6. |
Biological Terror – Toxins |
| 25.6.1. |
Botulinum Toxin |
| 25.6.2. |
Ricin |
| 25.6.3. |
Saxitoxin |
| 25.6.4. |
Staphylococcal Enterotoxin B (SEB) |
| 26. |
Appendix B: Bio-Detection – Patent Review |
| 26.1. |
Scope |
| 26.2. |
Bio-Detection Patents |
| 27. |
Appendix C: Legal Issues |
| 27.1. |
International / European Legislation / Agreements |
| 27.1.1. |
The Biological and Toxin Weapons Convention (BTWC) 1972 |
| 27.2. |
U.S. Bioterrorism Legislation |
| 27.3. |
The European Treaties & Legislation |
| 27.3.1. |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |