| 1 |
Executive Summary |
| 1.1 |
Main Findings |
| 1.2 |
Main Conclusions |
| 1.3 |
Global Bio-Detection Market 2011-2016 |
| 1.3.1 |
Global Systems, Service & Upgrade Markets 2011-2016 |
| 1.3.2 |
Markets by Countries & Regions 2011-2016 |
| 1.3.3 |
Markets by Outdoor, Indoor, Hand-Held and Mobile Lab 2011-2016 |
| 1.3.4 |
Systems Market by Technology Generation 2011-2016 |
| 1.3.5 |
Service & Upgrade Market by Generation 2011-2016 |
| 1.4 |
Business Opportunities |
| 1.4.1 |
Bio-Surveillance, Detection & Bio-forensics Business Challenges 2011-2016 |
| 1.5 |
Technology Outlook |
| 2 |
Introduction |
| 2.1 |
Scope |
| 2.2 |
Who is This Report For? |
| 2.3 |
Methodology |
| 2.4 |
Terms of Reference |
| 3 |
Bio-Terror |
| 4 |
Forty Countries: Bio-Security Status Review |
| 4.1 |
Background |
| 4.2 |
Forty Countries Bio-Technology & Bio-Defense Performance Score |
| 5 |
Bio-Detection Market Drivers |
| 6 |
Bio-Detection Market Inhibitors |
| 7 |
Bio-Detection Industry Competitive Analysis |
| 8 |
Industry SWOT Analysis |
| 8.1 |
Scope |
| 8.2 |
SWOT Analysis |
| 9 |
The Bio-Detection Process |
| 9.1 |
Sampling the Environment |
| 9.2 |
Bio-Detectors in a Multitude of Ambient Settings |
| 9.3 |
Bio-Detection Triggering |
| 9.4 |
Sample Collection |
| 9.5 |
Bio-Particle Detectors |
| 9.6 |
Bio-Agent Identification |
| 10 |
Bio-Detection Technological Challenges |
| 10.1 |
Challenge 1 Detection of Small Particle Concentration |
| 10.2 |
Challenge 2 Bio-Background Suppression |
| 10.3 |
Challenge 3 Expensive Reagents |
| 10.4 |
Challenge 4 Expensive Equipment Maintenance |
| 10.5 |
Challenge 5 Adapting Equipment to Changing Environments |
| 10.6 |
Challenge 6 Dealing With Emerging Threats |
| 11 |
Present and Pipeline Bio-Detection Technologies |
| 11.1 |
Bio-Detection Core Technologies Comparison |
| 11.2 |
Collector/Concentrator Core Technologies |
| 11.3 |
Cyclone Collectors |
| 11.4 |
Variable Particle-Size Impactor |
| 11.5 |
Virtual Impactors |
| 11.6 |
Impingers |
| 11.7 |
Reagent-less Trigger Core Technologies |
| 11.7.1 |
Flow Cytometry |
| 11.7.2 |
Particle Sizing |
| 11.7.3 |
Gas Chromatography |
| 11.7.4 |
Trigger Technologies Drivers |
| 11.7.5 |
Trigger Technologies Inhibitors |
| 11.8 |
DNA Based Diagnostic Core Technologies |
| 11.8.1 |
Overview of DNA-Based Detection |
| 11.8.2 |
Polymerase Chain Reaction (PCR) |
| 11.8.3 |
DNA / RNA Microarrays |
| 11.8.4 |
DNA Technology Drivers |
| 11.8.5 |
DNA Technology Inhibitors |
| 11.9 |
Antibody-Antigen Diagnostic Core Technologies |
| 11.9.1 |
Overview of Antibody-Antigen Reaction |
| 11.9.2 |
Hand-Held Immuno-Chromatographic Assays (HHA) |
| 11.9.3 |
Magnetic Microbead-Base Assays |
| 11.9.4 |
Microfluidic Devices “Lab on a Chip” |
| 11.9.5 |
Fluorescence Imaging |
| 11.9.6 |
Electrochemical-Luminescence (ECL) |
| 11.9.7 |
Antibody/Antigen Technology Drivers |
| 11.9.8 |
Antibody/Antigen Technology Inhibitors |
| 11.1 |
Signal Analysis Algorithms |
| 11.10.1 |
Clustering / Classifier Algorithms |
| 11.10.2 |
Image Analysis Algorithms |
| 11.10.3 |
Decision Algorithms |
| 11.10.4 |
Drivers |
| 11.10.5 |
Inhibitors |
| 11.11 |
Rapid Microbiological Technologies |
| 12 |
Bio- Detection Analysis by Application |
| 12.1.1 |
Application 1 Emergency Responder Hand-Held Detectors |
| 12.1.2 |
Application 2 Emergency Responder Mobile Labs |
| 12.1.3 |
Application 3 Indoor Standoff Detectors |
| 12.1.4 |
Application 4 Outdoor Standoff Detectors |
| 13 |
Global Bio- Detection Market 2011-2016 |
| 13.1 |
The Global Market Overview |
| 13.2 |
Market by Systems, Upgrade and Service Segments 2011-2016 |
| 13.3 |
Global Market by Countries & Regions 2011-2016 |
| 13.4 |
Global Systems Market by Technological Generation 2011-2016 |
| 13.5 |
Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments 2011-2016 |
| 13.6 |
Global Service & Upgrade Market 2011-2016 |
| 13.6.1 |
Global Service and Upgrade Business by Technological Generation 2011-2016 |
| 13.6.2 |
Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments 2011-2016 |
| 14 |
US Bio-Detection Market 2011-2016 |
| 14.1 |
US Bio-Defense Background & Analysis |
| 14.2 |
The Obama Administration Bio Terror Mitigation Strategy |
| 14.3 |
Biosurveillance Network |
| 14.4 |
Bio-Defense Funding |
| 14.4.1 |
Overview |
| 14.4.2 |
DHHS Bio-Defense Missions and Funding |
| 14.4.3 |
DHS Bio-Defense Missions and Funding |
| 14.4.4 |
DOD Bio-Defense Missions and Funding |
| 14.4.5 |
DOA Bio-Defense Missions and Funding |
| 14.4.6 |
EPA Bio-Defense Missions and Funding |
| 14.5 |
Leading Bio-Security Projects |
| 14.5.1 |
Project BioWatch |
| 14.5.2 |
Project BioSense |
| 14.5.3 |
Project BioShield |
| 14.6 |
Market Drivers |
| 14.7 |
Market Inhibitors |
| 14.8 |
US Bio-Detection Systems Market 2011-2016 |
| 14.8.1 |
Sales by Generation Forecast |
| 14.8.2 |
US Bio-Detection Systems Market by Modality Forecast |
| 14.9 |
US Outdoor Standoff Bio-Detection Systems Market 2011-2016 |
| 14.9.1 |
Sales Outlook |
| 14.1 |
US Indoor Bio-Detection Systems Market 2011-2016 |
| 14.10.1 |
Indoor Market Outlook |
| 14.11 |
US Hand-Held Detection Systems Market 2011-2016 |
| 14.11.1 |
Hand-Held Detection Systems Market Outlook |
| 14.12 |
US Mobile Bio-Detection Labs Market 2011-2016 |
| 14.12.1 |
Market Outlook |
| 14.13 |
US Service Business 2011-2016 |
| 14.13.1 |
Service & Upgrade Business by Modality 2011-2016 |
| 14.13.2 |
Service Business by Generation 2011-2016 |
| 15 |
The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market |
| 15.1 |
The European Union |
| 15.1.1 |
The European Union Bio-Defense Background |
| 15.1.2 |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |
| 15.1.3 |
EU Bio-Defense Research Programs |
| 15.2 |
The UK |
| 15.2.1 |
Bio-Defense Strategy |
| 15.2.2 |
Main Bio-Defense Initiatives |
| 15.3 |
Germany |
| 15.3.1 |
Bio-Defense Strategy |
| 15.3.2 |
Main Bio-Defense Initiatives |
| 15.3.3 |
Bio- Detection R&D Projects |
| 15.4 |
France |
| 15.5 |
Italy |
| 15.6 |
Spain |
| 15.7 |
Market Drivers |
| 15.8 |
Market Inhibitors |
| 15.9 |
UK, Germany, France, Italy and Spain Bio-Detection Systems Market 2011-2016 |
| 15.9.1 |
Sales by Technology Generations Forecast |
| 15.9.2 |
Sales by Modality Forecast |
| 15.1 |
UK, Germany, France, Italy and Spain Outdoor Standoff Bio-Detection Systems Market Forecast 2011-2016 |
| 15.10.1 |
Systems Market Outlook |
| 15.11 |
UK, Germany, France, Italy and Spain Indoor Bio-Detection Systems Market 2011-2016 |
| 15.11.1 |
Systems Market Outlook |
| 15.12 |
UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market 2011-2016 |
| 15.12.1 |
Systems Market Outlook |
| 15.13 |
UK, Germany, France, Italy and Spain Mobile Bio-Detection Labs Market 2011-2016 |
| 15.13.1 |
Market Outlook |
| 15.14 |
UK, Germany, France, Italy and Spain Service Business 2011-2016 |
| 15.14.1 |
Service & Upgrade Business by Modality 2011-2016 |
| 15.14.2 |
Service Business by Generation 2011-2016 |
| 16 |
China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market |
| 16.1 |
Asian Countries Bio- Defense Background |
| 16.2 |
Japan |
| 16.3 |
China |
| 16.4 |
Taiwan |
| 16.5 |
India |
| 16.6 |
Singapore |
| 16.7 |
Middle East |
| 16.8 |
Market Drivers |
| 16.9 |
Market Inhibitors |
| 16.1 |
China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market 2011-2016 |
| 16.10.1 |
Sales by Technology Generation 2011-2016 |
| 16.10.2 |
Market by Modality 2011-2016 |
| 16.11 |
China, Taiwan, Japan, India and Middle East Bio-Detection Outdoor Systems Market 2011-2016 |
| 16.11.1 |
Sales Outlook |
| 16.12 |
China, Taiwan, Japan, India and Middle East Bio-Detection Indoor Systems Market 2011-2016 |
| 16.12.1 |
Market Outlook |
| 16.13 |
China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market 2011-2016 |
| 16.13.1 |
Market Outlook |
| 16.14 |
China, Taiwan, Japan, India and Middle East Bio-Detection Mobile Labs Market 2011-2016 |
| 16.14.1 |
Market Outlook |
| 16.15 |
China, Taiwan, Japan, India and Middle East Service Business 2011-2016 |
| 16.15.1 |
Service & Upgrade Business by Modality 2011-2016 |
| 16.15.2 |
Service Business by Generation 2011-2016 |
| 17 |
The Rest of the World HLS-HLD Bio-Detection Market |
| 17.1 |
ROW: Bio-Defense Background |
| 17.1.1 |
Russia and CIS |
| 17.1.2 |
Russian Government Bio-Security Initiatives |
| 17.1.3 |
International Science and Technology Center (ISTC) |
| 17.1.4 |
Canada |
| 17.1.5 |
Australia |
| 17.2 |
Market Drivers |
| 17.3 |
Market Inhibitors |
| 17.4 |
ROW Bio-Detection Systems Market 2011-2016 |
| 17.4.1 |
Sales Forecast by Generation |
| 17.4.2 |
Market by Modality Forecast |
| 17.5 |
ROW Outdoor Bio-Detection Systems Market 2011-2016 |
| 17.5.1 |
Sales Outlook |
| 17.6 |
ROW Indoor Bio-Detection Systems Market 2011-2016 |
| 17.6.1 |
Market Outlook |
| 17.7 |
ROW Hand-Held Detection Systems Market 2011-2016 |
| 17.7.1 |
ROW Market Outlook |
| 17.8 |
ROW Mobile Bio-Detection Labs Market 2011-2016 |
| 17.8.1 |
Market Outlook |
| 17.9 |
ROW Service Business 2011-2016 |
| 17.9.1 |
ROW Service & Upgrade Business by Modality |
| 17.9.2 |
Service Business by Generation 2011-2016 |
| 18 |
Bio-Detection Business Opportunities 2011-2016 |
| 18.1 |
Historical Perspective: A Market Waiting for Transition |
| 18.1.1 |
The Current and Future HLS Bio-Defense Strategy for Detection |
| 18.1.2 |
Factors Affecting Biological Detectors Deployment and Technologies 2011-2016 |
| 18.1.3 |
Biological Detection Technology Timeline |
| 18.2 |
Business Opportunities for Next Generation HLS Bio-Detection Systems |
| 18.2.1 |
Business Opportunity 1 Emerging Threats |
| 18.2.2 |
Business Opportunity 2 Human Sentinel Surveillance System |
| 18.2.3 |
Business Opportunity 3 Animal Sentinel Surveillance System |
| 18.2.4 |
Business Opportunity 4 Biological IC3 Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure |
| 18.2.5 |
Business Opportunity 5 Reducing False Alarms Less False Positives and False Negatives |
| 18.2.6 |
Business Opportunity 6 Reducing Cost Minimizing Use of Non-Reusable Reagents |
| 18.3 |
Outdoor Standoff Biological Detectors |
| 18.3.1 |
Business Opportunity 7 Bio-agent Autonomous Networked Detectors (BAND) |
| 18.3.2 |
Business Opportunity 8 Rapid Automated Biological Identification System (RABIS) |
| 18.3.3 |
Business Opportunity 9 First Responder Portable Hand-Held Detector |
| 18.3.4 |
Business Opportunity 10 First-Responder Mobile Biological Detection Station |
| 18.3.5 |
Business Opportunity 11 Regional Automatic Detector Outdoor Standoff Detectors |
| 18.3.6 |
Business Opportunity 12 Networked Automatic Detector Indoor Standoff Detectors |
| 18.3.7 |
Business Opportunity 13 External Dissemination of Bio-Agent Detection |
| 18.3.8 |
Business Opportunity 14 Internal Dissemination of Bio-Agent |
| 18.4 |
Other Bio-Detection Technologies Business Opportunities |
| 18.4.1 |
Business Opportunity 15 “Lab on a Chip” Miniature Detection Devices |
| 18.4.2 |
Business Opportunity 16 Reagent-less Specific Detection Assays |
| 18.4.3 |
Business Opportunity 17 Laser-Induced Breakdown Spectroscopy (LIBS) |
| 18.4.4 |
Business Opportunity 18 Raman Spectroscopy-based Reagent-less Detection |
| 18.5 |
Future Technologies and Systems |
| 19 |
Vendors |
| 19.1 |
20/20 GeneSystems Inc. |
| 19.2 |
Advnt Biotechnologies |
| 19.3 |
Agilent Technologies |
| 19.4 |
Alexeter Technologies |
| 19.5 |
ANP Technologies, Inc. |
| 19.6 |
BAS – Biological Alarm Systems Ltd. (Israel) |
| 19.7 |
BD Biosciences Immunocytometry Systems |
| 19.8 |
Bertin Technologies |
| 19.9 |
BioDefense Corporation |
| 19.1 |
BioDETECT AS |
| 19.11 |
BioSentinel Pharmaceuticals LLC |
| 19.12 |
3M Microbiology (Biotrace International, Ltd.) |
| 19.13 |
BioTraces, Inc. |
| 19.14 |
BioVeris Corporation |
| 19.15 |
Biral |
| 19.16 |
Cepheid |
| 19.17 |
Commonwealth Biotechnologies, Inc. |
| 19.18 |
Dycor Technologies Ltd. |
| 19.19 |
Environics Oy |
| 19.2 |
Evogen, Inc. |
| 19.21 |
General Dynamics Canada |
| 19.22 |
GenPrime, Inc. |
| 19.23 |
Groton Biosystems |
| 19.24 |
Haztech Systems, Inc. |
| 19.25 |
Idaho Technology, Inc. |
| 19.26 |
JMAR Technologies, Inc. |
| 19.27 |
New Horizons Diagnostics |
| 19.28 |
Proengin |
| 19.29 |
QTL Biodetection |
| 19.3 |
Research International |
| 19.31 |
Response Biomedical |
| 19.32 |
Roche Applied Science |
| 19.33 |
Smiths Detection |
| 19.34 |
Tetracore, Inc. |
| 20 |
Prices of Bio-Detection Equipment |
| 21 |
Appendix A: The Threat of Bio-Terror |
| 21.1 |
Biological Terror |
| 21.2 |
Bio-Weapons Historical Perspective |
| 21.3 |
Biological Terror Bacterial Agents |
| 21.3.1 |
Anthrax |
| 21.3.2 |
Cholera |
| 21.3.3 |
Plague |
| 21.3.4 |
Tularemia |
| 21.4 |
Biological Terror Viral Agents |
| 21.4.1 |
Smallpox |
| 21.4.2 |
Hemorrhagic Fever Viruses |
| 21.4.3 |
Venezuelan Equine Encephalitis |
| 21.5 |
Biological Terror Rickettsiae Agents |
| 21.5.1 |
Q Fever |
| 21.5.2 |
Typhus |
| 21.6 |
Biological Terror Toxins |
| 21.6.1 |
Botulinum Toxin |
| 21.6.2 |
Ricin |
| 21.6.3 |
Saxitoxin |
| 21.6.4 |
Staphylococcal Enterotoxin B (SEB) |
| 22 |
Appendix B: Legal Issues |
| 22.1 |
International / European Legislation / Agreements |
| 22.1.1 |
The Biological and Toxin Weapons Convention (BTWC) 1972 |
| 22.2 |
U.S. Bioterrorism Legislation |
| 22.3 |
The European Treaties & Legislation |
| 22.3.1 |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |